Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Identifieur interne : 004B30 ( Main/Exploration ); précédent : 004B29; suivant : 004B31Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase
Auteurs : D. Xu [République populaire de Chine] ; Z. Zhang [République populaire de Chine] ; L. Jin [République populaire de Chine] ; F. Chu [République populaire de Chine] ; Y. Mao [République populaire de Chine] ; H. Wang [République populaire de Chine] ; M. Liu [République populaire de Chine] ; M. Wang [République populaire de Chine] ; L. Zhang [République populaire de Chine] ; G. F. Gao [République populaire de Chine] ; F. S. Wang [République populaire de Chine]Source :
- European Journal of Clinical Microbiology and Infectious Diseases [ 0934-9723 ] ; 2005-03-01.
Descripteurs français
- KwdFr :
- ARN viral (isolement et purification), ARN viral (sang), ARN viral (urine), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Convalescence, Facteurs temps, Femelle, Fèces (virologie), Humains, Immunoglobuline G (sang), Immunoglobuline M (sang), Mâle, Sujet âgé, Syndrome respiratoire aigu sévère (urine), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification).
- MESH :
- isolement et purification : ARN viral, Virus du SRAS.
- sang : ARN viral, Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- virologie : ARN viral, Adulte, Adulte d'âge moyen, Convalescence, Facteurs temps, Femelle, Fèces, Humains, Mâle, Sujet âgé, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Adult, Aged, Antibodies, Viral (blood), Convalescence, Feces (virology), Female, Humans, Immunoglobulin G (blood), Immunoglobulin M (blood), Male, Middle Aged, RNA, Viral (blood), RNA, Viral (isolation & purification), RNA, Viral (urine), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (urine), Severe Acute Respiratory Syndrome (virology), Time Factors.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M, RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- chemical , urine : RNA, Viral.
- isolation & purification : SARS Virus.
- urine : Severe Acute Respiratory Syndrome.
- virology : Feces, Severe Acute Respiratory Syndrome.
- Adult, Aged, Convalescence, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
Abstract: In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.
Url:
- https://api.istex.fr/ark:/67375/VQC-JGTFBLWX-0/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088045
DOI: 10.1007/s10096-005-1299-5
Affiliations:
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Le document en format XML
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Xu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. Zhang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L." last="Jin">L. 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Liu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. 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Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, D" sort="Xu, D" uniqKey="Xu D" first="D." last="Xu">D. Xu</name></noRegion><name sortKey="Chu, F" sort="Chu, F" uniqKey="Chu F" first="F." last="Chu">F. Chu</name><name sortKey="Gao, G F" sort="Gao, G F" uniqKey="Gao G" first="G. F." last="Gao">G. F. Gao</name><name sortKey="Jin, L" sort="Jin, L" uniqKey="Jin L" first="L." last="Jin">L. Jin</name><name sortKey="Liu, M" sort="Liu, M" uniqKey="Liu M" first="M." last="Liu">M. Liu</name><name sortKey="Mao, Y" sort="Mao, Y" uniqKey="Mao Y" first="Y." last="Mao">Y. Mao</name><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><name sortKey="Wang, F S" sort="Wang, F S" uniqKey="Wang F" first="F. S." last="Wang">F. S. Wang</name><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><name sortKey="Zhang, L" sort="Zhang, L" uniqKey="Zhang L" first="L." last="Zhang">L. Zhang</name><name sortKey="Zhang, Z" sort="Zhang, Z" uniqKey="Zhang Z" first="Z." last="Zhang">Z. Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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